Built in 1691-94 and 1728-34 in Spaso-Andronikov Monastery.

Initially in 1504-1505 by the order of Ivan III the brick refectory and one-pillar chamber on the second floor (three-row curb of cornice – the XVII-th century) were built. Under the cornice there can be found a band of red tiles. In 1691-1694 for the money given by the first wife of Peter I, the empress Evdokiya Lopukhina, a three-high church in the manner of Moscow baroque was attached to the eastern facade. It was designated for the creation of the table-tomb of the Lopukhin family. Its third level is occupied by the Church of Saint Aleksiy, metropolite of Moscow (celestial patron of tsarevich Aleksiy, son of Evdokiya Lopukhina and Peter I, who was born in 1690). After Evdokiya Lopukhina took the veil (1694) further construction works were stopped. They continued after her coming back to Moscow upon accession of Peter II (1727), son of tsarevich Aleksei Petrovich, her grandson. In 1728-1734 above the three-high church the octangular dome completed by a miniature drum was overbuilt. Due to its height it dominates in the ensemble of the monastery. It was damaged by fires (1748, 1812, 1919), it was under repair (1777-80, 1819, 1825, 1864), but it has not been subject to reconstruction. Wall-painting was lost at the beginning of the XX-th century.

The Church was closed in 1924.

Since 1960-s it has been hosting expositions of Andrey Rublev’s Central Museum of the Old Russian Culture and Art.